Evaluation of Antidiabetic Activity of Novel Diarylsulfonylurea-Chalcone Hybrids in Streptozotocin-Induced Diabetic Models in Rats
Main Article Content
Abstract
Introduction: The aim of the study was to evaluate the diabetic activity of diarylsulfonylurea-chalcone hybrids on streptozotocin (STZ)-induced diabetic male albino rats. Materials and Methods: Diabetic activity of diarylsulfonylurea-chalcone hybrids at a dose of 10, 30, and 50 mg/kg body weight was evaluated. Adult male Swiss albino rats of six numbers in each group were undertaken for study and evaluated. Results: The results of in vivo hypoglycemic and antihyperglycemic activity of the synthesized diarylsulfonylurea-chalcone hybrid molecules (II.1-28) showed that all the compounds were found to possess moderate to potential ability to reduce blood glucose levels in normoglycemic and STZ-induced type 2 diabetic rats. Conclusions: The diarylsulfonylurea-chalcone hybrids have potent diabetic activity in the male albino rat.
Downloads
Download data is not yet available.
Article Details
How to Cite
Naidu, M. A. (2018). Evaluation of Antidiabetic Activity of Novel Diarylsulfonylurea-Chalcone Hybrids in Streptozotocin-Induced Diabetic Models in Rats. Asian Journal of Pharmaceutics (AJP), 12(01). https://doi.org/10.22377/ajp.v12i01.2464
Section
ORIGINAL ARTICLES
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.