Development of natural gum based fast disintegrating tablets of glipizide
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Abstract
gum disintegrated within a minute and fulfilled the official requirements for dispersible tablets. As the amount of guar gum increased, the friability increased and hardness decreased, resulting in a shorter wetting and disintegration time. Gum acacia and gum tragacanth did the opposite.The glipizideâ€loaded fast disintegrating tablet prepared with 18 mg of guar gum gave a friability
of 0.46 ± 0.02%, content uniformity of 99.34 ± 0.82%, drug content of 99.15 ± 1.16%, wetting time of 39.0 ± 1.04 sec, hardness of 5.70 ± 1.41 Kg and disintegration time less than 30 sec, suggesting that it was a practical product with a good tablet property. In conclusion, natural gum based patientâ€friendly fast disintegrating tablets of glipizide can be successfully formulated.
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