Novel Techniques to Make Innumerable, Expectedly Safe, and Oily Systems to Make Intramuscular Injections (Solutions) of Poorly Oil Soluble Drugs Using Mixed Solvency Concept

Abstract

A large number of blends of oily solutions containing oil soluble safe additives can be developed. The primary goal of
the present study is to investigate the idea of mixed solvency concept. Pharmaceutical manufacturers can then use these
blends to develop oily solutions for intramuscular injections that contain drugs that are poorly oil soluble. The main
objective of this research is to provide oily intramuscular injection manufacturers some creative ideas. Utilizing the
solubilizing properties of safe solubilizers, the solubility of poorly oil soluble drugs can be increased. After toxicological
studies, it is anticipated that these injection formulations will be safe and such formulations can be marketed by the
pharmaceutical manufacturers. According to the mixed solvency concept, every substance on earth has the ability to
dissolve a solute in a solvent system. Hence, a concentrated oily solution containing a variety of oil soluble excipients
might work well as a solvent for drugs that are poorly oil soluble. Such a concentrated solution might demonstrate the
additive or synergistic solubilizing effects of the solubilizers present in solution for a specific solute.