Formulation and Evaluation of Candesartan Cilexetil Fast-Dissolving Tablets Using Natural Superdisintegrant

Abstract

Introduction: Candesartan Cilexetil is a BCS class II drug having low water solubility, which can be enhanced
by formulating them in to solid dispersions by using hydrophilic carriers and compressed in to fast dissolving
tablets by using natural superdisintegrants. Materials and Methods: The solubility and dissolution rate of
Candesartan Cilexetil were aimed to be increased in this investigation by employing fusion process to create a
solid dispersion with a hydrophilic carrier like PVP or PEG 6000. Additionally, utilising Croscarmelose sodium
(CCS) and Aegle marmelos as superdisintegrants, the solid dispersion was compressed into fast dissolving tablets.
Results and Discussion: The drug release increased proportionately with increase in carrier concentration.
Among the solid dispersions prepared, the one made with PEG6000 released the medication more rapidly
than the one made only with PVPK30 and pure drug. First order kinetics were found to determine the release.
Conclusion: The prepared solid dispersions were then mixed with super-disintegrants like Croscarmelose
sodium (CCS) and Aegle marmelos to produce tablets. Such tablet formulations have been observed to release
drug more rapidly than tablets prepared from pure drug. FTIR and XRD tests are used to characterise the pure
drug and optimised formulation F6. Results showed that there were no drug and excipient interactions.