Polyelectrolyte Complex-based Multiparticulate Drug Delivery System: A Special Emphasis on Chitosan and Alginate

Abstract

Effective drug delivery systems play a pivotal role in optimizing therapeutic outcomes and minimizing side
effects. This study explores the potential of a multiparticle drug delivery system incorporating chitosan, alginate,
and polyelectrolyte as a versatile platform for controlled and targeted drug release. These materials offer distinct
attributes that synergistically enhance drug bioavailability, stability, and release kinetics. With its bioadhesive
properties and biocompatibility, chitosan promotes prolonged residence time in the gastrointestinal tract, thereby
improving drug absorption. Alginate contributes to the system’s stability and protection of encapsulated drugs,
while also allowing modulation of release profiles. The inclusion of polyelectrolytes offers an additional layer of
control over swelling behavior and encapsulation efficiency. The multiparticulate nature of the system addresses
challenges associated with dose uniformity and release consistency. This approach provides advantages in terms of
enhanced drug dispersion, reduced risk of dose dumping, and potential for tailored release patterns. Furthermore,
the system’s adaptability enables the design of complex delivery strategies, including sequential or combination
therapies. However, formulation optimization remains a critical factor in achieving desired release profiles
and therapeutic effects. Challenges in maintaining batch consistency and scaling up production also warrant
consideration. As the field of pharmaceutical science continues to advance, this multiparticulate drug delivery
system holds promise for revolutionizing drug administration, resulting in safer and more effective treatments
for various medical conditions. Further research and development in this area are warranted to fully harness its
potential.