Advances and Challenges in Mucoadhesive Drug Delivery Systems: A Comprehensive Review

Abstract

Pharmaceutical research has focused a lot of emphasis on the capability of mucoadhesive drug delivery systems
to enhance patient compliance and therapeutic effectiveness. This thorough analysis examines the most recent
developments as well as the ongoing difficulties in the discipline of mucoadhesive drug delivery. It explores the
mechanics of mucoadhesion, emphasizing the complex relationships that exist among mucoadhesive polymers
and mucosal surfaces. In addition, it covers the range of uses for mucoadhesive systems in oral, nasal, ocular,
and vaginal delivery, among other modes of administration. The analysis sheds light on the design techniques
used to maximize mucoadhesive formulations for better bioavailability, prolonged release, and targeted drug
delivery. It also discusses the safety profiles and regulatory issues related to mucoadhesive products. The potential
of mucoadhesive drug delivery systems to raise treatment effectiveness and patient compliance has attracted a
lot of attention in pharmaceutical research. This thorough analysis examines the most recent developments as
well as the ongoing difficulties in the discipline. It explores the mechanics of mucoadhesion, emphasizing the
complex relationships that exist among mucoadhesive polymers and mucosal surfaces. In addition, it covers
the range of uses for mucoadhesive systems in oral, nasal, ocular, and vaginal delivery, among other modes of
administration. The analysis sheds light on the design techniques used to maximize mucoadhesive formulations
for better bioavailability, prolonged release, and targeted drug delivery. It also discusses the safety profiles and
regulatory issues related to mucoadhesive products. Even with the tremendous advancements, several issues
including scalability, clinical translation, and formulation stability still need to be resolved. This study assesses
mucoadhesive drug delivery systems critically, notes new developments, and suggests possible avenues to go over
current obstacles and realize the full promise of these cutting-edge drug delivery platforms.