Liquid Chromatography–Mass Spectrometry Study Focusing on Neuroprotective Effect of Compounds Obtained from Bacopa monnieri Juice

Abstract

Introduction: According to Ayurvedic literature, Brahmi is highly recommended for the management of
psychiatric problems since it acts on the brain. In traditional Ayurvedic medicine, Brahmi, a herb is recommended
for the management of various psychological disorders such as Alakshmi (inauspicious condition), Unmada
(insanity), and Apasmara (epilepsy). Drug quality is a basic necessity in this day and age, and analytical testing
can help combat impurities or subpar pharmaceuticals. Materials and Methods: Compound analysis of Brahmi
Juice ( Swarasa) using liquid chromatographic mass spectrometry (LC-MS). Results: LC-MS analysis shows
major compound such as L-Phenylalanine, Phenylacetylene, DL-Arginine, Azelaic acid, Erucamide, D-(+)-
Pyroglutamic acid, L-Glutamic acid, Valine, Choline, L-Isoleucine, DL-Tryptophan, L-(-)-Methionine, and
Beta-Ionone which play a significant role in neuroprotection. Conclusion: The study showed the presence of
compounds rich in neurotransmitters which also act as neurotonics having their specific neuroprotective effect
in conditions such as Alzheimer’s Disease, Parkinsonism, and Dementia. By employing a wide array of testing
procedures, manufacturers are able to ensure compliance with regulatory requirements and supply consumers with
a better product that effectively delivers Brahmi’s therapeutic benefits.