Ameliorative Effects of MnO Nanoparticles on Acute Kidney Injury Model in Rats
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Abstract
Aims: Acute kidney injury (AKI) is described as an abrupt and generally reversible damage of renal function
that occurs over days or weeks. Nearly 20% of nephrotoxicity is associated with the use of antimicrobials and
antibiotics. Materials and Methods: The evaluation of the possible protective effect of MnO nanoparticles (NPs)
as well as explore their toxic effects on the kidneys of rat models. MnO NPs were prepared and evaluated for their
physicochemical properties. The effect of MnO NPs was compared with gentamicin. Results and Discussion: In vivo
data showed no toxicity according to zootechnical parameters, blood biochemistry, and organ system toxicity in
MnO NP treatment groups. The protective effect of the MnO NPs group as compared to the gentamicin treatment
group was observed. Conclusion: Hence, using the MnO NPs will help improve the AKI values.
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