SOLUBILITY ENHANCEMENT STRATEGIES FOR POORLY WATER-SOLUBLE DRUGS IN SOLID DISPERSIONS: A REVIEW
Main Article Content
Abstract
Solid dispersions have been employed to enhance the dissolut ion rates of poor ly water - soluble drugs.
Many approaches have been invest igated for the preparat ion of solid dispersions. This paper repor ts
various solubility enhancement strategies in solid dispersion. The approaches described are fusion (melting),
solvent evaporation, lyophilization (freeze drying), melt agglomeration process, extruding method,
spray drying technology, use of surfactant, electro static spinning method and super critical fluid technology.
The paper also highlights the potential applications and limitations of these approaches in solid
dispersions
Downloads
Article Details
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.