EFFECT OF PERMEATION ENHANCERS ON PERMEATION KINETICS OF MIDAZOLAM, IN- VITRO CHARACTERIZATION
Main Article Content
Abstract
Buccal drug delivery system has seen a veritable explosion in the past decades. In the present scenario,
very few buccal patches are commercially available. Midazolam being an ant i-psychot ic drug requires
chronic administ rat ion. Since the drug has an extensive first pass metabolism and is available in the
invasive intramuscular form, an attempt was made to develop buccal drug delivery system for patient
compliance. In this study, flux and permeation enhancement trials of midazolam was carried out using
modified Franz diffusion cells through porcine buccal mucosa. The permeabilit y co-efficient , flux, and
enhancement ratio of drug with hyaluronidase was found to be 31.256cm/hr. 156.28 μg/cm 2/hr and 2
respectively. Currently, in this article chitosan and its derivatives viz partially O- and N-Acetylated chitosan
and N-Acetylated chitosan were used t o study the suitabilit y for the buccal drug delivery systems and
midazolam was used as a model drug.
Downloads
Article Details
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.