FORMULATION DEVELOPMENT AND EVALUATION OF FLUCONAZOLE GEL IN VARIOUS POLYMER BASESFORMULATION DEVELOPMENT AND EVALUATION OF FLUCONAZOLE GEL IN VARIOUS POLYMER BASES

BIDKAR DEVENDRA JAIN

Abstract


Topical drug delivery systems of Fluconazole, antifungal drug in the form of gels were formulated using
polymers like HPMC, Carbopol 934, Methylcellulose and Sodium alginate. The gels were evaluated for
various physicochemical parameters like pH, viscosity, rheology, drug content , spreadibilit y and skin
irritation test. In addition, in vitro drug release by diffusion using cellophane membrane and permeation
through hairless rat skin using modified Kiesery Chien Diffusion cell was performed. The rheological
behaviour and apparent viscosity values for different gel bases were measured before and after storage
under freezing condition at 2-8 0C and were taken as measure for stability of gel network structure. Also
accelerated stability testing at 45±2 0C and 75%±5% R.H for 3 months were performed. Among the four
formulat ions, gel prepared using HPMC shows desired propert ies and exhibit bet ter release pat tern
when compared with other formulations prepared with Carbopol, Sodium alginate and Methylcellulose


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DOI: http://dx.doi.org/10.22377/ajp.v1i1.742

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