STUDIES OF OLEORESINS AS PENETRATION ENHANCER FOR TRANSDERMAL PATCH OF KETOPROFEN

Abstract

The study deals wit h the effect of oleoresins (nutmeg, capsicum, coriander and garlic) as penet rat ion
enhancer for t ransdermal pat ch of ketoprofen. The t ransdermal patch prepared by mercury subst rate
technique and evaluated. I n vit ro release was found t o be more than 60% through rat skin and 70%
through cellophane membrane in capsicum oleoresin. In vivo study indicated that capsicum had 80.56
edema inhibit ions and t ransdermal patch without penet rat ion enhancer had 65.84 edema inhibit ions.
This indicated that the formulat ion containing oleoresin capsicum had high % edema inhibit ion. The
more skin permeability and greatest flux of ketoprofen was obtained significantly by capsicum oleoresin.
From Overall study, it can be concluded that to deliver the drug through the skin, penetration enhancer
play a vital role. So to deliver the drug into systemic circulation at predetermined rate by transdermal
therapeutic system of Ketoprofen, using natural oleoresins as penetration enhancer.
In nutshell the oleoresins like Oleoresin nutmeg, Oleoresin capsicum, Oleoresin garlic, Oleoresin coriander
shows penet rabilit y and drug wit h maximum flux. Amongst this oleoresin capsaicin shows bet ter
performance as penetration enhancer.