Formulation of povidone iodine toothpaste and evaluation of its chemical stability

Abstract

The aim of this study is to formulate a toothpaste containing povidone-iodine (PVP-I) and evaluate its chemical stability.PVP-I was incorporated into toothpastes from different trademarks and a new toothpaste formulation containing PVP-I was also prepared. The obtained toothpastes were coded as F1, F2, F3 and F4, respectively. Chemical stability of PVP-I in the formulations (according to the USP method) was checked over a period of 7 weeks. Color, pH and smell of the obtained toothpaste formulations were evaluated. PVP-I in F1, F2 and F3 toothpastes was stable over the 7-week period in the first
two formulations and for only 4 weeks in the last one. However, PVP-I was only stable for a period of 3 weeks when it was the only active ingredient as in F4. The pH of the formulations remained constant for the entire study period for all
formulations. No changes in viscosity, smell or color of all the toothpaste formulations were observed. The compounding of PVP-I toothpaste in order to achieve oral hygiene can be achieved successfully. Attention should be made by practicing pharmacists with regard to the exact expiry dates of the obtained formulations.