@article{Nanda_2022, title={Molecular Characterization of Extended Spectrum Β-Lactamase Producing Escherichia Coli Isolated From Urine Samples}, volume={16}, url={http://asiapharmaceutics.info/index.php/ajp/article/view/4480}, DOI={10.22377/ajp.v16i3.4480}, abstractNote={<p>Aim: The upsurge in multiple antibiotic resistance strains of pathogenic bacteria has become one of the biggest<br>concern for the past 25 years. Research states that the developments of resistance to multiple drugs are primarily<br>due to the antibiotic resistant genes acquisition through grouped in multifaceted clusters, transposons, and plasmids.<br>Materials and Methods: The collected urine samples were polymerase chain reactions (PCR)-screened for<br>the confirmation of Escherichia coli and the presence of multiple antibiotic resistant markers blaCTX-M coding<br>the most common resistant phenotypes established in enteric bacteria group. Results and Discussion: During the<br>present study, pathogenic isolates of extended-spectrum β-lactamase (ESBL) producing E. coli causing urinary<br>tract infections (UTI) infections from different hospital environments were detected for their virulence gene using<br>PCR; further, they were examined for antibiotic sensitivity patterns against varied therapeutic drugs available in<br>the marketplaces. It was found that the antibiotic sensitivity was high for Carbapenems followed by Ofloxacin<br>and Doxycycline hydrochloride. Moreover, least sensitivity was recorded for Cephalosporin. The present study<br>found that UTI initiated by Pathogenic ESBL producing E. coli among nosocomial infections which are to be<br>high among the persons with immunologically suppressed. Conclusion: Drug resistant E. coli may be freely<br>come across in hospital locations during every day clinical practices and the urologists must act untimely. The<br>organization of this infection is exceedingly significant for forthcoming research with specific allusion to prevent<br>of fresh antibiotic resistant pattern.</p>}, number={3}, journal={Asian Journal of Pharmaceutics (AJP)}, author={Nanda, Anima}, year={2022}, month={Sep.} }