TY - JOUR AU - Daud, Anwar S AU - Sapkal, Nidhi P AU - Bonde, Minal N PY - 2014/08/27 Y2 - 2024/03/28 TI - Development of Zingiber officinale in oral dissolving films: Effect of polymers on in vitro, in vivo parameters and clinical efficacy JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 5 IS - 3 SE - Articles DO - 10.22377/ajp.v5i3.105 UR - http://asiapharmaceutics.info/index.php/ajp/article/view/105 SP - AB - Oral dissolving drug delivery system offers a solution for those patients having difficulty in swallowing tablets/capsules,etc. Zingiber officinale, has been used for medicinal purpose since antiquity to treat motion sickness, pregnancy, and<br />cancer-chemotherapy-induced vomiting, mild stomach upset, cough, chronic bronchial problems, and low-grade infections of all kinds and anorexia condition. This work investigates the possibility of developing Zingiber officinale oral dissolving films allowing fast, reproducible dissolution in oral cavity; thus bypassing first pass metabolism. The oral dissolving films were prepared by solvent-casting method. Prepared films were evaluated for film-forming properties, physico-mechanical properties, palatability, microbial limit test, accelerated stability studies, and clinical efficacy test. The different polymers<br />such as hydroxypropyl methylcellulose 5cps, maltodextrin, pullulan, and polyvinyl alcohol were explored individually and in combination with each other for the formation of film. Among all polymers, maltodextrin and HPMC 5 cps alone and<br />in combination showed excellent film-forming properties as well as very good physico-mechanical properties. The films resulted into excellent palatability along with least disintegrating time. But at accelerated stability studies, only HPMC 5<br />cps was found to be stable when compared with other formulations. So, it was concluded that HPMC 5 cps is the best film forming as well as stable polymer with respect to Zingiber officinale oral dissolving film.<br /><br /> ER -