TY - JOUR AU - Patel, Rakesh P AU - Baria, Ashok H AU - Patel, Nikunjana A PY - 2014/08/25 Y2 - 2024/03/29 TI - An overview of size reduction technologies in the field of pharmaceutical manufacturing JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 2 IS - 4 SE - Articles DO - 10.22377/ajp.v2i4.202 UR - http://asiapharmaceutics.info/index.php/ajp/article/view/202 SP - AB - Size reduction is a process of reducing large solid unit masses into small unit masses, coarse particles or fine particles. Size reduction process is also termed as comminution or diminution or pulverizations. In addition to the standard adjustments of the milling process (i.e., speed, screen size, design of rotor, load), special techniques of milling may be useful including special<br />atmosphere, temperature control, sonocrystallization, supercritical fluid process. etc. Moreover, some advance technologies of size reduction including Micron Technologies, Gran-U-LizerTM Technology, Jet-O-MizerTM and Microfluidics® have<br />been popular. Various application of size reduction concept covers oral delivery of poorly soluble drugs, micronization, nanotechnology (micro- and nano suspensions), etc.This systemic review highlights advantages and disadvantages, mechanisms, theories, techniques, advances, and pharmaceutical applications of size reduction technology.<br /><br /> ER -