TY - JOUR AU - Mehta, Dharmik M. AU - J. Dave, Divyang AU - Dadhaniya, Dhaval V. AU - Shelat, Pragna K. AU - Parejiya, Punit B. AU - S. Barot, Bhavesh PY - 2014/08/30 Y2 - 2024/03/29 TI - Application of Box-Behnken design to formulate and optimize multipolymeric fast dissolving film of rizatriptan benzoate JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 8 IS - 1 SE - Articles DO - 10.22377/ajp.v8i1.320 UR - http://asiapharmaceutics.info/index.php/ajp/article/view/320 SP - AB - The present investigation aims at formulation and optimization of multipolymeric fast dissolving film of rizatriptan benzoate.<br />Three film forming polymers namely hydroxypropyl methylcellulose (HPMC), maltodextrin and polyvinylalcohol were<br />explored using Box-Behnken experimental design to derive optimized fast dissolving film formulation using desirability function.<br />Analysis of variance (ANOVA) was performed for five dependent variables tensile strength, folding endurance, load at yield,<br />percentage elongation and percentage drug release in 30 s (Q30). Mathematical regression equations were derived by applying<br />ANOVA and validated using checkpoint batches. Results of the experimental design exposed that the effect of independent<br />factors HPMC and maltodextrin significantly influenced the mechanical properties and percentage drug release from the<br />film. Optimized batch was derived based on set criteria using desirability function. Reponses of the optimized formulation<br />were tensile strength (500 N/m2), folding endurance (203), load at yield (15.06 N/m2), percentage elongation (4.56%) and<br />Q30 (60.03%) falling under acceptable limits. High percentage drug release from the film in simulated saliva and simulated<br />gastric fluid reveal fast dissolving characteristics. Fast dissolving dosage form can help patients with diseases like migraine ER -