TY - JOUR AU - Akhali, Khaled M Al AU - Alavudeen, Sirajudeen S PY - 2014/10/02 Y2 - 2024/03/29 TI - Multiple dose of liquid antacid enhance simvastatin bioavailability in Malaysian male volunteers JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 8 IS - 2 SE - Articles DO - 10.22377/ajp.v8i2.344 UR - http://asiapharmaceutics.info/index.php/ajp/article/view/344 SP - AB - The effect of a liquid antacid on the oral bioavailability of simvastatin 40 mg tablet was evaluated in 9 healthy Malaysian<br />male volunteers in a randomized, single dose, two‑way crossover study. The drug was administered following an overnight<br />fast or a liquid antacid. The plasma concentration of simvastatin was determined by using a validated HPLC-MS-MS method.<br />An effect of liquid antacid on the bioavailability was indicated 95% increase in the AUC of simvastatin with antacid state<br />comparing to fasting state. The study was concluded that liquid antacid had effect on the increasing pH of gastrointestinal<br />tract which leads to increasing the lactone form of simvastatin stability and improve the dissolution of the drug by increasing<br />gastric residence time. This study revealed that simvastatin is pH‑dependent.<br />Key words: Liquid antacid, fasting, simvastatin bioavailability ER -