TY - JOUR AU - Ivanna, V. Sakhanda PY - 2020/06/09 Y2 - 2024/03/29 TI - Comparison of the Expression of Antihypertensive Action of Preparation of Different Clinical and Pharmacological Groups JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 14 IS - 2 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v14i2.3624 UR - http://asiapharmaceutics.info/index.php/ajp/article/view/3624 SP - AB - <p>Introduction: Increased blood pressure (BP) is one of the most significant epidemiological, medical, social,<br />and economic consequences of problems. The results of many studies indicate that in one-third of people in<br />Ukraine, the level of BP exceeds 140/90 mm Hg, it is increased. There is a contradiction between the need to<br />adhere to the current level of therapy, which involves the use of new, as a rule, expensive techniques and drugs,<br />and the constant lack of funding for health care. Materials and Methods: Methods of statistical description,<br />systematic, sociological, economic, and statistical analysis, including variational statistics, correspondence<br />questionnaires, and expert assessments, were used in the research process. The study included 1568 patients<br />diagnosed with hypertension. As a result of the pharmacoepidemiological analysis, it was shown that the most<br />often antihypertensive monotherapy is performed for younger patients with initial lower BP values. Results: A<br />more detailed analysis of the antihypertensive activity of drugs belonging to the main pharmacological groups was<br />performed with arterial hypertension monotherapy. Therefore, it is important to analyze the therapeutic efficacy<br />of antihypertensive drugs from different clinical and pharmacological groups, safety, and their impact on the wellbeing<br />of patients. Discussion and Conclusion: Analysis of the structure of prescriptions revealed the dominant<br />positions of Agriculture Commercialization Equity Fund drugs, and, above all, drugs enalapril, among patients<br />with hypertension in all study groups, regardless of age and gender, as well as regimens of antihypertensive<br />therapy. A retrospective study of the antihypertensive effect of drugs from different clinical and therapeutic groups<br />revealed no significant differences, but significant differences were noted when comparing the original drugs with<br />their reproduced analogs (generics)</p> ER -