TY - JOUR AU - Venu, Dr. Kola PY - 2020/07/22 Y2 - 2024/03/28 TI - Anti-ulcer Potential of Aqueous and Ethanolic Bark Extracts of “Saraca indica” Using Different Screening Models JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 14 IS - 03 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v14i03.3691 UR - http://asiapharmaceutics.info/index.php/ajp/article/view/3691 SP - AB - <p>Objective: Saraca indica (Cesalpiniaceae) is a plant, reported for its variety of ethnic medicinal uses, and widely<br />grown in Asia, Africa, and the Caribbean for its edible bark. The present work has been planned to screen the antiulcer<br />activity of bark of the plant with the ethanolic and aqueous extracts. Materials and Methods: Bark powder<br />was successively extracted with ethanol (95%) and water using Soxhlet extraction and subjected to phytochemical<br />screening to identify different phytoconstituents. Ld50 studies for both (ethanolic and aqueous) extracts were<br />conducted up to the dose level of 2 g/kg by following OECD up-and-down method of guidelines No.425. The antiarthritic<br />activity was performed using pylorus ligation, aspirin, and stress-induced ulcer models in rats. Statistical<br />analysis was performed using one-way analysis of variance (ANOVA) followed by Dunnett’s test. P &lt; 0.05 was<br />considered statistically significant. Results: Preliminary phytochemical studies revealed the presence of saponins,<br />sterols, mucilage, glycosides, and alkaloids, steroidal saponins in both the ethanolic and aqueous extracts of<br />S. indica. No mortality was observed with aqueous and ethanolic extracts up to the maximum dose level of 2 g/kg.<br />Both the extracts except with low dose 100 mg/kg other two doses, that is, medium and high have significantly<br />reduced the ulcer number (0.83 ± 0.0.16, 1.5 ± 0.34 and 0.50 ± 0.11, 0.66 ± 0.21), ulcer score (1.5 ± 0.12, 1.66<br />± 0.16 and 0.83 ± 0.10, 0.91 ± 0.15), and ulcer index (13.64, 9.80 and 11.20, 8.25), and a significantly ulcer<br />inhibition (41.10%, 27.30% and 68.76%, 54.25%) is noted. Conclusion: From the present experimental findings<br />of both pharmacological and biochemical parameters observed from the current investigation, it is concluded that<br />the doses of 200 mg/kg and 400 mg/kg aqueous extract of S. indica possess potentially useful anti-ulcer activity<br />since it gives a positive result in ulcer score and ulcer index and a significant ulcer inhibition.</p> ER -