TY - JOUR AU - Khan, Abdulla PY - 2020/09/18 Y2 - 2024/03/28 TI - Formulation and Evaluation of Flurbiprofen Solid Dispersions using Novel Carriers for Enhancement of Solubility JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 14 IS - 03 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v14i03.3765 UR - http://asiapharmaceutics.info/index.php/ajp/article/view/3765 SP - AB - <p>Introduction: The main objective of the current study is to enhance the solubility and dissolution of poorly<br />water-soluble drug flurbiprofen, a propionic acid derivative, used as non-steroidal anti-inflammatory drug by<br />formulating into solid dispersion (SD) employing various hydrophilic polymers as carriers in the formulation.<br />Materials and Methods: The solubility of drug in various polymers such as AQOAT AS, PVP-K30,<br />hydroxypropryl methyl cellulose, Soluplus, and Kollidon VA 64 was studied. Total 15 SD formulations were<br />prepared by solvent evaporation technique with different polymers and were evaluated for particle size analysis,<br />% practical yield, drug content determination, and in vitro dissolution studies. Results: Based on the evaluation<br />parameters and dissolution studies, SD6 was found to be optimized formulation. The SD6 prepared using<br />flurbiprofen:AQOAT AS:sodium lauryl sulfate as drug:polymer:surfactant in 1:5:2 ratios showed maximum<br />drug release of 99.86 in 15 min when compared with other formulation and the solubility of the formulation<br />SD6 was enhanced 44 folds when compared to that of pure drug. Drug excipient compatibility studies were<br />conducted using FTIR and XRD and scanning electron microscope (SEM) studies were also conducted. FTIR<br />studies showed the compatibility between drug and polymers. XRD and SEM studies showed that the optimized<br />formulation was in amorphous form which fetched in better dissolution of the drug from the SD formulation<br />when compared to the pure drug. Conclusion: This indicates the formulation technology employed with a<br />potential of enhancing bioavailability of poorly water-soluble drug by improving its dissolution rate.</p> ER -