TY - JOUR AU - Kulkarni, Deepak PY - 2021/04/05 Y2 - 2024/03/29 TI - Accidental Formation of Eutectics during Crystal Engineering of Lamotrigine with Solubility Advantage and Drug Release Efficiency JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 15 IS - 1 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v15i1.3960 UR - http://asiapharmaceutics.info/index.php/ajp/article/view/3960 SP - AB - <p>Objective: Lamotrigine (LMG) is the Biopharmaceutical Classification System Class-II drug with hurdle in drug<br />release and dissolution efficiency due to poor water solubility. The present investigation was aimed to improve<br />the solubility and dissolution of LMG by crystal engineering by formation of cocrystals but which accidently<br />turn toward eutectics formation. Methods: LMG was subjected to neat grinding with different Cocrystal Formers<br />(CCF) to develop multicomponent crystalline system. The prepared multicomponent system was analyzed by<br />Differential Scanning Calorimetry, Raman spectroscopy, and Powder X-ray Diffraction reveals the formation<br />of multicomponent system. Improved dissolution was interpreted by comparative drug release study of tablet<br />formulation of unprocessed drug and eutectics. Results: There was unplanned formation of eutectics of LMGAscorbic<br />acid (LMG-AA) that was observed with improved drug solubility. LMG-AA eutectics showed<br />enhanced solubility (651.61 ± 1.02 μg/ml) in comparison with pure drug (161.46 ± 0.86 μg/ml) and all remaining<br />multicomponent systems formed with other CCF’s. The LMG-AA eutectics showed comparatively better drug<br />release than pure LMG tablet. LMG eutectics also showed significant improvement in flow properties and<br />compressibility as compared to pure drug. Conclusion: Multicomponent LMG-AA eutectics although formed in<br />unplanned way they effectively enhances the solubility of LMG serving the main purpose of the research work. It<br />can be utilized efficiently for drug delivery due to its improved dissolution and better drug release.</p> ER -