TY - JOUR AU - Chauhan, Rajendra PY - 2022/06/15 Y2 - 2024/03/28 TI - A Design of Experiment-based Approach for the Formulation Development and Evaluation of Repaglinide Transdermal Patch Using Natural Polymers JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 16 IS - 2 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v16i2.4398 UR - http://asiapharmaceutics.info/index.php/ajp/article/view/4398 SP - AB - <p>Aim: The main aim of this study was to Formulation and Characterization of Repaglinide Transdermal Patch Using<br>Natural polymers. Materials and Methods: The Box–Behnken design was used, which has three levels and three<br>factors to investigate the associate impact of significant attributes on tensile strength, In vitro drug release, and Ex<br>vivo drug permeation. Fifteen formulations were developed that differed in the polymer ratio (9:1, 8:1, and 7:1).<br>The permeation of repaglinide through hairless goat ear skin through Ex vivo was found to increase with the help<br>of permeation enhancer d-limonene. Results: As per the experimental data, it is concluded that the R12 is the best<br>formulation in ex vivo permeation, in which we have taken 30% propylene glycol as a plasticizer, 3% d-limonene<br>as a permeation enhancer, and this formulation shown 301.825 μg/cm2 permeation in 24 h. Conclusion: After<br>optimizing all formulations, it concluded that the ratio of polymer in 9:1, 3% of a permeation enhancer, and 30%<br>plasticize was the optimum quantity of different excipients used in the optimized formulation. These findings<br>suggest that transdermal repaglinide delivery may have therapeutic promise, with benefits such as reduced dose<br>frequency, better patient compliance, non-invasive properties, enhanced bioavailability, and ease of medication<br>discontinuation.</p> ER -