TY - JOUR AU - Sonawane, Deepak D. PY - 2022/12/15 Y2 - 2024/03/29 TI - Formulation, Development, and Evaluation of Sustained Release Tablet of Ambroxol Hydrochloride JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 16 IS - 4 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v16i4.4603 UR - http://asiapharmaceutics.info/index.php/ajp/article/view/4603 SP - AB - <p>Introduction: Ambroxol hydrochloride tablet was formulated as sustained release tablets employing rice bran wax<br>polymer and the sustained release behavior of the fabricated tablets were investigated. Materials and Methods: The<br>objectives of study are Sustained release matrix tablets containing 75 mg ambroxol hydrochloride were developed<br>using different drug polymer ratios of MCC, RBW and DCP. Tablets were prepared by direct compression.<br>Formulation was optimized on the basis of acceptable tablet properties and in vitro drug release and by using<br>23 factorial designs. Result and Discussion: The resulting formulation produced robust tablets with optimum<br>hardness, consistent weight uniformity and low friability. All tablets but one exhibited gradual and near-completion<br>sustained release for ambroxol hydrochloride, and 98-103% released at the end of 8 h. Conclusion: The results of<br>dissolution studies indicated that formulation F7, the most successful of the study, exhibited drug release pattern<br>very close to theoretical release profile. A decrease in release kinetics of the drug was observed on increasing<br>polymer ratio. Applying exponential equation, all the formulation tablets (except F7) showed diffusion-dominated<br>drug release. The mechanism of drug release from F7 was diffusion with erosion.</p> ER -