TY - JOUR AU - Kaushik, Dinesh PY - 2016/06/29 Y2 - 2024/03/29 TI - Baicalein Loaded Polysorbate 80 Nanostructured Lipid Carriers Offered Enhanced Stability and In Vitro Drug Release JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 10 IS - 2 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v10i2.635 UR - http://asiapharmaceutics.info/index.php/ajp/article/view/635 SP - AB - Aim: The aim of this work was to characterize baicalein loaded nanostructured lipid carriers (NLCs) intended for brain targeting by intravenous route of administration. Materials and Methods: The NLC system, composed of stearic acid and polysorbate 80, was characterized in terms of its physicochemical properties, differential scanning calorimetry (DSC), and in vitro drug release. Results and Discussion: The lipid nanoparticles were spherical with an average size of ∼100 nm. The zeta potential of the nanoparticles was about −50 mV. DSC studies suggested that the majority of the inner cores of polysorbate 80 NLCs had a slightly disordered crystal arrangement. The nanoparticulate dispersions demonstrated good physical stability during storage for 6 days. Conclusion: Polysorbate 80 NLCs improved baicalein’s stability and the ability of baicalein to penetrate the brain; thus, this is a promising drug-targeting system for the treatment of central nervous system. ER -