@article{Derle_Bele_Kasliwal_2014, title={In vitro and in vivo evaluation of mefenamic acid and its complexes with β-Cyclodextrin and HP-β-Cyclodextrin}, volume={2}, url={https://asiapharmaceutics.info/index.php/ajp/article/view/167}, DOI={10.22377/ajp.v2i1.167}, abstractNote={The objective of this research was to improve solubility, dissolution, and, consequently, bioavailability of mefenamic acid, a poorly water-soluble nonsteroidal anti-inflammatory drug, by complexation with β-Cyclodextrin and<br />HP-β-Cyclodextrin. The complexes of mefenamic acid with β-Cyclodextrin and HP-β-Cyclodextrin were prepared by kneading method and were characterized and evaluated to study the effect of complexation on dissolution profiles and<br />in vivo advantage. The complexes were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, and differential scanning calorimetry studies. Phase solubility studies indicated complex formation with possible stoichiometry of 1:1 and a stability constant of 176 M-1 for β-Cyclodextrin and 103.8 M-1 for HP-β-Cyclodextrin. The characterization studies confirmed the inclusion of mefenamic acid within the nonpolar cavity of β-Cyclodextrin and of HP-β-Cyclodextrin. Remarkable improvement was observed in the in vitro drug release profiles in 0.1-N HCl and pH-6.8 phosphate buffer with<br />all complexes. Mefenamic acid also showed improvement in the in vivo activity when administered orally to rats as compared<br />with mefenamic acid per se.<br /><br />}, number={1}, journal={Asian Journal of Pharmaceutics (AJP)}, author={Derle, Deelip V and Bele, Mrudula and Kasliwal, Nikhil}, year={2014}, month={Aug.} }