@article{Soumya_Chowdary_Swapna_Prathyusha_Geethika_Jyostna_Krishna Mohan_2014, title={Preparation and optimization of sustained release matrix tablets of metoprolol succinate and taro gum using response surface methodology}, volume={8}, url={https://asiapharmaceutics.info/index.php/ajp/article/view/319}, DOI={10.22377/ajp.v8i1.319}, abstractNote={In the present study, an effort was made to formulate and evaluate matrix tablets of tarogum utilizing metaprolol succinate<br />as the model drug. 32 full optimization procedure was adopted where two factors are studied at three levels. The amount<br />of taro gum (X1) and polyvinylpyrrolidone (PVP) K30 (X2) were selected as independent variables. The time required<br />for 90% of drug release was selected as the dependent variable. Tablets were prepared by direct compression and were<br />evaluated for various post compression parameters such as tablet hardness, friability, weight variation, drug content and<br />in vitro dissolution. The results were found to be within the acceptable limits. The release exponent (n) lies between 0.416<br />and 0.584 indicating drug release from the matrix tablets may be fickian or non‑fickian (anomalous) depending upon the<br />concentration of natural polymer. T90 was 10.70, 11.20, 12.05, 12.66 h for B6, B7, B8 and B9 batches respectively showing<br />overriding potential of taro gum, but still the effect of PVP K 30 is noteworthy. PVP K 30 has an indirect effect on all the<br />factors by increasing tensile strength and making the tablet firm and intact.}, number={1}, journal={Asian Journal of Pharmaceutics (AJP)}, author={Soumya, M. and Chowdary, Y. A. and Swapna, V. Naga and Prathyusha, N. D. and Geethika, R. and Jyostna, B. and Krishna Mohan, K.Sai}, year={2014}, month={Aug.} }