@article{R. Madan_Sudarshan_Kadam_Kama_2014, title={Formulation and development of self-microemulsifying drug delivery system of pioglitazone}, volume={8}, url={https://asiapharmaceutics.info/index.php/ajp/article/view/323}, DOI={10.22377/ajp.v8i1.323}, abstractNote={Self-microemulsifying drug delivery system (SMEDDS) is a promising system for the Biopharmaceutics Classification<br />System (BCS) class II drugs. The current research aimed to improve the dissolution of poorly water-soluble antidiabetic<br />drug pioglitazone HCl by formulating it in SMEDDS. Liquid SMEDDS of pioglitazone HCl were formulated with Capmul<br />MCM C8 and oleic acid as oil phase, Cremophor RH 40 and Tween 80 as surfactant phase, and Transcutol P as cosurfactant<br />phase after screening various vehicles. The prepared formulations were evaluated for self-emulsifying ability and phase<br />diagram was constructed to optimize the system. These systems were further characterized for globule size, effect of pH<br />and robustness, zeta potential, drug content, viscosity, self-emulsification time, polydispersity index, % transmittance,<br />thermodynamic stability, surface morphology, and drug release. The system was robust to different pH media and dilution<br />volumes. The optimized system possessed a mean globule size of 122.2 nm, zeta potential around -22.9 mV, drug content<br />99.66 ± 0.47%, viscosity 0.8874 ± 0.026 cP, emulsification time 38 s, polydispersity index value of 0.5, and transmittance<br />value of 99.3 ± 0.6%. Drug release in hydrochloric acid buffer pH 2 was found to be 99.35 ± 0.38%. More than three-fold<br />increase in dissolution characteristics of pioglitazone HCl in SMEDDS was observed as compared to pure and marketed<br />formulation. Liquid SMEDDS filled in hard gelatin capsule (HGC) shell was found to be compatible. Stability studies show<br />there was no sign of phase separation or precipitation and no change in drug content was observed.}, number={1}, journal={Asian Journal of Pharmaceutics (AJP)}, author={R. Madan, Jyotsana and Sudarshan, Bandavane and Kadam, Vinod S. and Kama, Dua}, year={2014}, month={Aug.} }