@article{Hiremath_Raghavendra_Sunil_Danki_Rampure_Swamy_Bhosale_2014, title={Dissolution enhancement of gliclazide by preparation of inclusion complexes with β-cyclodextrin}, volume={2}, url={https://asiapharmaceutics.info/index.php/ajp/article/view/335}, DOI={10.22377/ajp.v2i1.335}, abstractNote={Gliclazide is an oral hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus. The drug is<br />practically insoluble in water and exhibits an exceedingly slow intrinsic dissolution rate and poor bioavailability. The<br />present study has emphasized on improving the solubility and dissolution rate of the drug by forming inclusion complex<br />with β-cyclodextrin. Phase solubility studies indicated the formation of 1:2 M complex in solution. The value of apparent<br />stability constant Kc was found to be 691.45 M–1. The inclusion complexes were prepared by physical mixture and kneading<br />method. Prepared complexes were characterized by infrared (IR) spectroscopy and differential scanning calorimetry (DSC)<br />studies, which indicated formation of 1:2 M complex. The gliclazide:β-CD (1:2 M) complex prepared by kneading method<br />exhibited higher dissolution rate and dissolution efficiency values in 0.1-N HCl. A 20.31-fold increase in dissolution rate<br />and 16.50-fold increase in dissolution efficiency values were observed in the kneading method.<br />Key words: β-cyclodextrin, gliclazide, kneading method, physical mixture}, number={1}, journal={Asian Journal of Pharmaceutics (AJP)}, author={Hiremath, S N and Raghavendra, R K and Sunil, F and Danki, L S and Rampure, M V and Swamy, P V and Bhosale, U V}, year={2014}, month={Oct.} }