@article{Das_2021, title={Lipid-polycaprolactone Core-shell Hybrid Nanoparticles for Controlled Delivery of Nateglinide}, volume={15}, url={https://asiapharmaceutics.info/index.php/ajp/article/view/4059}, DOI={10.22377/ajp.v15i2.4059}, abstractNote={<p>Objective: Lipid-polymer hybrid nanoparticles (LPHNPs) combine the biomimetic advantages of lipids and the<br />structural benefits of polymers. The aim of the present study is the development of core shell LPHNPs encapsulating<br />a model lipophilic drug nateglinide and perceived its controlled delivery. Materials and Methods: LPHNPs<br />were prepared by single emulsion solvent evaporation method using polycaprolactone as polymer and glyceryl<br />monostearate, palmitic acid, and lauric acid as lipid. The formulations were characterized in terms of particle<br />size, zeta potential, drug entrapment efficiency, drug loading (DL), surface morphology, in vitro drug release,<br />and release kinetics studies. Results: Dynamic light scattering analysis demonstrated the smaller particle size<br />of LPHNPs (380.2 ± 3.5–544.7 ± 2.8 nm) as compared to polycaprolactone polymeric NPs (PNPs) (647.1 ±<br />1.9–675.8 ± 3.7 nm). Transmission electron microscopy images of LPNPs and PNPs demonstrate that they are<br />spherical in shape. The entrapment efficiencies (84.9 ± 0.1–87.76 ± 0.23%) and DL capacity (4.63 ± 0.01–8.18<br />± 0.09%) of LPHNPs were higher than PNPs (72.5 ± 0.1% and 2.05 ± 0.005%). The higher colloidal stability of<br />LPHNPs was confirmed by their zeta potential value at -12.5 ± 2.1––33.4 ± 0.2 mv as compared to zeta potential<br />of PNPs (–8.71 ± 0.3–9.60 ± 0.1 mv). The LPHNPs displayed a biphasic drug release pattern with an initial burst<br />release, followed by controlled release. The LPHNPs demonstrated the slower drug release (60–70% at 24 h) than<br />that from PNPs (90% at 24 h). Conclusion: The results suggest the controlled release behavior of nateglinide<br />from the developed lipid-polymer core shell hybrid NPs. The developed nanocarriers hold the great promise for<br />controlled delivery of both the lipophilic and hydrophilic drugs to improve their pharmacokinetics.</p>}, number={2}, journal={Asian Journal of Pharmaceutics (AJP)}, author={Das, Malay K.}, year={2021}, month={Jul.} }