@article{Srinivas_2021, title={Design and in vitro Evaluation of Fluvoxamine Nanosuspension using PVA as Stabilizing Agent}, volume={15}, url={https://asiapharmaceutics.info/index.php/ajp/article/view/4061}, DOI={10.22377/ajp.v15i2.4061}, abstractNote={<p>Introduction: Poor aqueous solubility and low dissolution rates are the initial drawback for the majority of<br />upcoming and existing biologically active compounds. Materials and Methods: Fluvoxamine (API), other<br />excipients such as PVA, SLS, Tween 80, and methanol. Fluvoxamine is a poorly water-soluble drug and its<br />bioavailability is very low. The present study was to increase the solubility and dissolution rate of Fluvoxamine<br />by formulating nanosuspensions by Emulsification solvent evaporation method. Results and Discussions: The<br />formulation nanosuspenison was subject to zeta potential, particle size analysis, drug content, and in vitro drug<br />release studies. The entrapment efficiency of all the formulations was within 95.78–98.16%, from the drug release<br />studies, The NF6 formulation was optimized and it shows maximum drug release (99.02%) at a shorter period<br />of time than remaining formulations. The average particle size of the optimized formulation was found to be<br />110 nm. Conclusion: The research showed that enhanced dissolution rate by reduced in particle size, which,<br />in turn, increases the dissolution rate and oral bioavailability of fluvoxamine by formulating nanosuspensions.<br />Formulations were found to physically stable with PVA as the stabilizing agent.</p>}, number={2}, journal={Asian Journal of Pharmaceutics (AJP)}, author={Srinivas, Martha}, year={2021}, month={Jul.} }