@article{Gawali_2021, title={Antihyperglycemic and Antihyperlipidemic Effect of Polyherbal Formulation on Alloxan-induced Diabetes in Wistar Rats}, volume={15}, url={https://asiapharmaceutics.info/index.php/ajp/article/view/4076}, DOI={10.22377/ajp.v15i2.4076}, abstractNote={<p>Objective: The polyherbal formulation (PHF) containing different herbal extracts has been used to treat<br />diabetic patients by Ayurvedic professionals in India. It has been well documented that the polyherbal<br />plant extracts more productively diminish the elevated blood glucose level as compared with the single<br />plant extract. Methodology: The PHF contains the concentrated extracts of Syzygium cumini, Annona<br />squamosa, Momordica charantia, Tinospora cordifolia, Gymnema sylvestre, and Curcuma longa. The<br />present study reports the impact of PHF alone and with metformin on various preclinical models of<br />hyperglycemia. Results: PHF treatment with alone and in combination with metformin evoked a noteworthy<br />antihyperglycemic impact on glucose loaded (P < 0.05), epinephrine-induced hyperglycemia (P < 0.05),<br />and alloxan-induced diabetic rats (P < 0.05). PHF treatment also modifies glucose tolerance curve pattern<br />both in normal and in diabetic rats. The treatment with polyherbal formulation was significantly improved<br />architecture of β-islets of Langerhans as compared with the diabetic rats. The PHF significantly decreased<br />(P < 0.05) triglyceride, cholesterol, and high-density lipoprotein as compared to diabetic control group.<br />The dynamic phytoconstituents present in this PHF are flavonoids, phenolic compound, triterpene saponins<br />like gymnemic acids, and gymnemasaponins advance the arrival of insulin and postpone the assimilation of<br />glucose. Conclusion: PHF treatment in combination with metformin is found to be useful in the management<br />of preclinically induced diabetes mellitus.</p>}, number={2}, journal={Asian Journal of Pharmaceutics (AJP)}, author={Gawali, Vikas B.}, year={2021}, month={Aug.} }