@article{Sonawane_2022, title={Formulation and Evaluation of Perindopril Erbumine Mouth Dissolving Film Using 32 Factorial Design}, volume={16}, url={https://asiapharmaceutics.info/index.php/ajp/article/view/4490}, DOI={10.22377/ajp.v16i3.4490}, abstractNote={<p>Introduction: The aim was to develop and optimize fast dissolving film of Perindopril Erbumine (PDP) by<br>two-factor, three-level factorial design as the two independent variables inclusive of X1 Hydroxypropyl<br>methylcellulose (HPMC) and X2 propylene glycol (PG) has been decided on the idea of the initial studies done<br>earlier than the experimental design is being implemented. Materials and Methods: HPMC E5 LV and PG<br>were used respectively as a film former and a plasticizer, to increase the physicochemical properties of the films,<br>organized by the solvent casting method. Result and Discussion: Structured or reaction variables included %<br>drug release in 10 min (Y1), disintegration time (Y2), and refolding strength (Y3). Basic reaction diagrams were<br>drawn, statistical validity of polynomials was established to identify optimized method compositions. The films<br>have undergone in vitro drug release studies which have confirmed 90.97–99.36% drug release within 10 min.<br>Ex vivo studies of optimized formulation confirmed 86% permeation of the drug through the oral mucosa of<br>sheep within 15 min and no cellular necrosis was found for the duration of the histological study. The stability of<br>optimized batch was found to be stable for 6 months under specified stability conditions. Conclusion: PDP mouth<br>dissolving film was formulated evaluated by using 32 factorial design.</p>}, number={3}, journal={Asian Journal of Pharmaceutics (AJP)}, author={Sonawane, Deepak D.}, year={2022}, month={Sep.} }