@article{Sonawane_2022, title={Formulation, Development, and Evaluation of Sustained Release Tablet of Ambroxol Hydrochloride}, volume={16}, url={https://asiapharmaceutics.info/index.php/ajp/article/view/4603}, DOI={10.22377/ajp.v16i4.4603}, abstractNote={<p>Introduction: Ambroxol hydrochloride tablet was formulated as sustained release tablets employing rice bran wax<br>polymer and the sustained release behavior of the fabricated tablets were investigated. Materials and Methods: The<br>objectives of study are Sustained release matrix tablets containing 75 mg ambroxol hydrochloride were developed<br>using different drug polymer ratios of MCC, RBW and DCP. Tablets were prepared by direct compression.<br>Formulation was optimized on the basis of acceptable tablet properties and in vitro drug release and by using<br>23 factorial designs. Result and Discussion: The resulting formulation produced robust tablets with optimum<br>hardness, consistent weight uniformity and low friability. All tablets but one exhibited gradual and near-completion<br>sustained release for ambroxol hydrochloride, and 98-103% released at the end of 8 h. Conclusion: The results of<br>dissolution studies indicated that formulation F7, the most successful of the study, exhibited drug release pattern<br>very close to theoretical release profile. A decrease in release kinetics of the drug was observed on increasing<br>polymer ratio. Applying exponential equation, all the formulation tablets (except F7) showed diffusion-dominated<br>drug release. The mechanism of drug release from F7 was diffusion with erosion.</p>}, number={4}, journal={Asian Journal of Pharmaceutics (AJP)}, author={Sonawane, Deepak D.}, year={2022}, month={Dec.} }