@article{Lanjhiyana_2022, title={Development and Characterization of Dual Cross-linked Microbeads for Colon Specific Targeting: Release Kinetic Modeling and Gamma Scintigraphy Studies}, volume={16}, url={https://asiapharmaceutics.info/index.php/ajp/article/view/4622}, abstractNote={<p>Objective: The aim of present study is to develop and characterize ionic gelation-based dual Ca2<br>+ and SO4<br>2- crosslinked<br>gel microbeads using blend mixture of biodegradable chitosan and sodium alginate for colon targeting.<br>Methods: Those diclofenac sodium (DS) loaded microbead formulations were prepared by utilizing ionic<br>gelation based polyelectrolyte complexes technique that was effectively dual cross-linked with Ca2<br>+ and SO4<br>2- ions<br>containing solutions. Results: The result for surface morphology characterization through scanning electron<br>microscopy revealed for semispherical and wrinkled shaped rough surfaces of those optimized formulations. The<br>mean particle size of 761.52–895.22 μm, entrapment efficiency 63.45–78.38% of, and percentage yield of 73.28–<br>78.69% are resulted, respectively. The swelling degree of those optimized formulations is found with slighter<br>values into acidic gastric medium (pH = 1.2), whereas increased values into alkaline intestinal mediums (pH = 6.8<br>and 7.4), respectively, during 4-h time intervals. The experimental vitro release studies revealed for negligible<br>amount of DS that was released into simulated gastric fluid medium during 2 h, while slower drug released<br>into simulated intestinal fluid medium during 3 h and augmented released into stem cell factor medium during<br>18 h studies, respectively. Furthermore, the drug release kinetics modeling studies performed for those optimized<br>formulations revealed for non-fickian mechanism type that was best fitted with Higuchi and Korsemeyer peppas<br>mathematical models. These confirmed that drug releases was guided by dual mechanisms of diffusion and<br>erosion simultaneously. Conclusion: The developed experimental formulations may be used for targeting of DS<br>into colon and possible management of inflammatory bowel disease, respectively.</p>}, number={4}, journal={Asian Journal of Pharmaceutics (AJP)}, author={Lanjhiyana, Dr. S. K.}, year={2022}, month={Dec.} }