@article{Rai_2023, title={The Development and Characterization of Eye Drops Containing Acyclovir Microspheres against Herpes Simplex-induced Keratitis}, volume={17}, url={https://asiapharmaceutics.info/index.php/ajp/article/view/4719}, DOI={10.22377/ajp.v17i1.4719}, abstractNote={<p>Objective: Acyclovir (ACV), a highly specific inhibitor of herpes virus replication, is applied topically<br>into the eye to treat ocular keratitis. The main aim of this study was to formulate and characterize eye drops<br>containing ACV microspheres against herpes simplex-induced keratitis. The microspheres are small spherical<br>particles with diameters ranging from 10 to 1000 μm. It increases bioavailability while decreasing side effects.<br>Materials and Methods: The solvent evaporation technique was used to develop the microspheres for the<br>sustained release drug delivery system. Crystalline methylcellulose, sodium alginate, calcium chloride, and<br>chitosan were the polymers used. The drug content, encapsulation efficiency, in vitro drug release studies, stability<br>studies, viscosity, pH measurement, and clarity test were all performed on the microspheres. Results: Particle size<br>and shape, percent entrapment, in vitro drug release, compatibility studies, and other characteristics of microsomes<br>were assessed. These drug delivery systems demonstrated good increased solubility and sustained release, which is<br>necessary for bioavailability and therapeutic action, due to their matrix nature. The formulation has an acceptable<br>shape and particle size, no chemical interactions, and is stable under refrigeration, according to the results of the<br>characterization parameters and stability research. Conclusion: Eye drops containing microspheres of ACV could<br>be considered a promising sustained drug delivery system for ocular keratitis treatment.</p>}, number={1}, journal={Asian Journal of Pharmaceutics (AJP)}, author={Rai, Neeta}, year={2023}, month={Mar.} }