@article{V_2016, title={ANALYSIS OF FORMULATION EFFECTS IN THE DISSOLUTION OF KETOPROFEN PELLETS}, volume={1}, url={https://asiapharmaceutics.info/index.php/ajp/article/view/746}, DOI={10.22377/ajp.v1i1.746}, abstractNote={<p>In this work the effects of citric acid and two common fillers, lactose (soluble) and tricalcium phosphate<br />(insoluble) are examined on the release profiles from pellets, using ketoprofen as a model drug with pHdependent<br />solubility. Also studies were conducted on dependence of these profiles on the specific surface<br />area, bulk density, apparent density, porosity and porosity parameters (pore size distribution, total<br />pore surface area, mean pore diameter and pore shape), as determined by mercury intrusion porosimetry.<br />Pellets were prepared by the extrusion-spheronization method. Four different formulations were considered:<br />two ternary mixtures of ketoprofen (I), lactose (L) or tricalcium phosphate (P) and microcel (M) in<br />the relative proportions 2:3:5 (ILM or IPM) and two four-component mixtures of the same components<br />plus 5% citric acid (C) in the relative proportions 2:2.5:0.5:5 (CILM or CIPM). Pellets with high porosity<br />and total pore sur face area but small median pore diameter ( t r icalcium phosphate pellets IPM) are<br />found to produce similar dissolution results to those of low porosity and low total pore surface area, but<br />having a high median pore diameter ( lactose pellets I LM) , ir respect ive of the solubility of excipients.<br />Addition of citric acid causes a delay in the initial dissolution for both formulations. During dissolution,<br />however, citric acid reduces the median pore diameter of lactose-based pellets. In contrast, in tricalcium<br />phosphate/ cit r ic acid pellet s (CIPM) , this parameter increases considerably dur ing dissolut ion, when<br />compared to the IPM formulat ion. These findings may just ify the cont rast ing dissolut ion behaviors of<br />CIPM and CILM (lactose/citric acid) pellets, after their common behavior in the initial stages, and show<br />that porosity and its related parameters, along with physical properties of excipients such as solubility,<br />density and specific surface area, are helpful to predict pellet behavior in drug release profiles.</p>}, number={1}, journal={Asian Journal of Pharmaceutics (AJP)}, author={V, SAINI}, year={2016}, month={Sep.} }