TY - JOUR AU - Totiger, Santosh B AU - Hiremath, Jagadeesh G PY - 2014/08/27 Y2 - 2024/03/28 TI - Paclitaxel loaded poly(sebacic acid-co-ricinoleic ester anhydride)-based nanoparticles JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 5 IS - 4 SE - Articles DO - 10.22377/ajp.v5i4.111 UR - https://asiapharmaceutics.info/index.php/ajp/article/view/111 SP - AB - The main objective of the present study was to prepare paclitaxel (PTX)-loaded poly(sebacic acid-co-ricinoleic ester anhydride) (poly (SA-RA) 70:30 w/w)-based nanoparticles (NPs). PTX- Poly (SA-RA) NPs were prepared by solvent<br />displacement technique. The prepared formulations were characterized in terms of particle size and distribution, surface morphology using Malvern laser analyzer, scanning electron microscope (SEM). Drug physical and chemical state were<br />determined by Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and differential scanning calorimetry. The particles obtained were spherical in shape with a smooth surface and mean particle size in the range of<br />443-436 nm. The entrapped PTX within the polymer matrix was in the form of amorphous state.<br /><br /> ER -