TY - JOUR AU - Derle, Deelip V AU - Bele, Mrudula AU - Kasliwal, Nikhil PY - 2014/08/28 Y2 - 2024/03/29 TI - In vitro and in vivo evaluation of mefenamic acid and its complexes with β-Cyclodextrin and HP-β-Cyclodextrin JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 2 IS - 1 SE - Articles DO - 10.22377/ajp.v2i1.167 UR - https://asiapharmaceutics.info/index.php/ajp/article/view/167 SP - AB - The objective of this research was to improve solubility, dissolution, and, consequently, bioavailability of mefenamic acid, a poorly water-soluble nonsteroidal anti-inflammatory drug, by complexation with β-Cyclodextrin and<br />HP-β-Cyclodextrin. The complexes of mefenamic acid with β-Cyclodextrin and HP-β-Cyclodextrin were prepared by kneading method and were characterized and evaluated to study the effect of complexation on dissolution profiles and<br />in vivo advantage. The complexes were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, and differential scanning calorimetry studies. Phase solubility studies indicated complex formation with possible stoichiometry of 1:1 and a stability constant of 176 M-1 for β-Cyclodextrin and 103.8 M-1 for HP-β-Cyclodextrin. The characterization studies confirmed the inclusion of mefenamic acid within the nonpolar cavity of β-Cyclodextrin and of HP-β-Cyclodextrin. Remarkable improvement was observed in the in vitro drug release profiles in 0.1-N HCl and pH-6.8 phosphate buffer with<br />all complexes. Mefenamic acid also showed improvement in the in vivo activity when administered orally to rats as compared<br />with mefenamic acid per se.<br /><br /> ER -