TY - JOUR AU - Sadashivaiah, R AU - Dinesh, B M AU - Patil, Uma A AU - Raghu, K S PY - 2014/08/28 Y2 - 2024/03/29 TI - Design and in vitro evaluation of haloperidol lactate transdermal patches containing ethyl cellulose-povidone as film formers JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 2 IS - 1 SE - Articles DO - 10.22377/ajp.v2i1.173 UR - https://asiapharmaceutics.info/index.php/ajp/article/view/173 SP - AB - Matrix-type transdermal drug delivery systems of haloperidol lactate were prepared using different ratios of ethyl cellulose (EC):polyvinyl pyrrolidone (PVP) (3:2, 2:3, 4:1, 1:2, 2:1, and 1:4) by solvent-evaporation technique.<br />Physicochemical parameters were characterized, and dissolution studies of the formulated films were performed. In addition, solubility studies at various values of pH were carried out, and partition coefficient in octanol/water system, flux, and enhancement ratio were also evaluated. In vitro permeation studies were done using modified Franz diffusion cells through human cadaver skin utilizing 20% PEG 400 in normal saline. Permeation studies illustrated that 4% hyaluronidase enzyme was a good enhancer. The prepared films were subjected to scanning electron microscopy (SEM) and fourier transform infrared spectroscopy (FT-IR) spectral analysis. Higuchi and Peppas models were used for optimizing the formulation.<br /><br /> ER -