TY - JOUR AU - Kumar, Narendra AU - Jain, Akhilesh K AU - Singh, Chhater AU - Kumar, Rajesh PY - 2014/08/28 Y2 - 2024/03/29 TI - Development, characterization and solubility study of solid dispersion of terbinafine hydrochloride by solvent evaporation method JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 2 IS - 3 SE - Articles DO - 10.22377/ajp.v2i3.211 UR - https://asiapharmaceutics.info/index.php/ajp/article/view/211 SP - AB - Terbinafine HCl (Poorly water soluble drug), when prepared as solid dispersion showed improved solubility and dissolution. So the main purpose of this investigation was to increase the solubility and dissolution rate of Terbinafine HCl by the preparation of its solid dispersion with polyvinyl pyrrolidone K30 using solvent evaporation methods. FT- IR spectra revealed no chemical incompatibility between drug and polyvinyl pyrrolidone K30. Drug-polymer interactions were<br />investigated using differential scanning calorimetry (DSC), Powder X-Ray Diffraction (PXRD).<br /><br /> ER -