TY - JOUR AU - Jayaprakash, S AU - Halith, S Mohamed AU - Firthouse, P U Mohamed AU - Kulaturanpillai, K AU - Abhijith, Abhijith AU - Nagarajan, M PY - 2014/08/25 Y2 - 2024/03/28 TI - Preparation and evaluation of biodegradable microspheres of methotrexate JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 3 IS - 1 SE - Articles DO - 10.22377/ajp.v3i1.237 UR - https://asiapharmaceutics.info/index.php/ajp/article/view/237 SP - AB - The objective of the present study is to prepare sustained-release methotrexate microspheres of bovine serum albumin<br />in different ratios by the emulsion cross-linking method. The prepared microspheres were subjected to various<br />physicochemical evaluation and in vitro release studies. The drug release from microspheres of 1:6 ratio is the most constant<br />and prolonged drug release is diffusion followed by erosion. The characteristics of the prepared microspheres are conducive<br />to the formulation of the sustained release drug delivery system. ER -