TY - JOUR AU - Khule, Prajakta K. PY - 2019/02/09 Y2 - 2024/03/29 TI - Formulation and Evaluation of Itraconazole Emulgel for Various Fungal Infections JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 13 IS - 01 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v13i01.3004 UR - https://asiapharmaceutics.info/index.php/ajp/article/view/3004 SP - AB - <p>Introduction: In the past few decades, there has been an exponential growth in the field of herbal medicine and<br />excipients. The aim of the present research work was to investigate the potential of emulgel in enhancing the<br />topical delivery of itraconazole using natural gelling agents. Materials and Methods: Emulgel formulations<br />of itraconazole were formulated using two types of gelling agents, namely xanthan gum and guar gum. The<br />influence of the type of the gelling agent and the concentration of both the oil phase and emulsifying agent on the<br />drug release from the formulated emulgel was studied by preparing various batches. The prepared formulations<br />were evaluated for their physical appearance, viscosity, drug release, globule size, skin irritation test, antifungal<br />activity, and stability. Itraconazole cream available in market was used for comparison with prepared formulations.<br />Results and Discussion: All the prepared emulgels showed acceptable physical properties concerning color,<br />homogeneity, consistency, spreadability, and pH value. The result of studied revealed that the optimized batch<br />shows 96.04% release in 5 h.</p> ER -