TY - JOUR AU - Alkrad, Jamal Alyoussef PY - 2019/05/07 Y2 - 2024/03/29 TI - Using Inverted Microemulsions for Transdermal Application of Folic Acid JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 13 IS - 02 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v13i02.3109 UR - https://asiapharmaceutics.info/index.php/ajp/article/view/3109 SP - AB - <p>Objectives: This study aimed to improve and assess the transdermal of folic acid through the skin through<br />non-ionic microemulsions (MEs). Methods and Instruments: Eight MEs were developed with different ratios<br />of Span 20-to-Tween 80 and folic acid contents. These MEs were characterized for their droplet sizes, rheological<br />properties. Besides, the encapsulation of folic acid insides the MEs was studied using Fourier-transform infrared<br />spectroscopy. Furthermore, the flux of formulated folic acid in MEs was evaluated using Franz diffusion cell.<br />Results: The MEs showed Newtonian viscosity and droplets sizes &lt;200 nm. However, the droplets sizes<br />increased with increasing Tween 80 and folic acid content. Furthermore, the flux of folic acid related to folic<br />acid concentration. However, using MEs, a high flux of 11.47 ± 6.9 × 10−4 μg/cm2 × h of folic acid through rat’s<br />skin could be achieved. Conclusion: The developed non-ionic MEs containing folic acid can be ideal carriers for<br />administration of folic acid transdermally.</p> ER -