TY - JOUR AU - Prasanthi, Dr. N. L. PY - 2019/07/27 Y2 - 2024/03/29 TI - Design and Development of Gastroretentive Tablets of Coccinia grandis leaf extract for treating Helicobacter pylori infection JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 13 IS - 3 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v13i3.3291 UR - https://asiapharmaceutics.info/index.php/ajp/article/view/3291 SP - AB - <p>Aim: To design and develop a gastroretentive herbal formulation of Coccinia grandis for the treatment of<br />Helicobacter pylori infection. Material and Methods: C. grandis extract was obtained by soxhlation process<br />with ethanol as the menstrum. The herbal gastroretentive tablets containing 200 mg of C. grandis ethanolic<br />extract were prepared by direct compression method using effervescent technique. HPMC K4M, HPMC K100M,<br />Carbopol and guar gum were used as retarding polymers at various concentrations. Sodium bicarbonate was used<br />at 20%w/w as gas generating agent and Avicel at 35%w/w as diluent. FTIR and DSC methods were employed<br />to investigate the drug-excipient interactions. The formulated tablets were evaluated for various quality control<br />parameters. Results and Discussion: The FTIR and DSC study revealed that there was no interaction between<br />the extract and the excipients. All the formulated tablets were within the quality control limits. The kinetic studies<br />specified that the release of extract from the gastroretentive tablets was by erosion-controlled diffusion mechanism.<br />Conclusion: The formulation having the combination of gum with HPMC K15M exhibited minimum floating lag<br />time and good release pattern which followed first-order kinetics.</p> ER -