TY - JOUR AU - Saikia, Pranjal AU - Sahu, Bhanu P. AU - Dash, S. K. PY - 2014/10/01 Y2 - 2024/03/28 TI - Mucoadhesive nanoparticles from tamarind seed polysaccharides for sustained delivery of anticancer drug irinotecan JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 7 IS - 4 SE - Articles DO - 10.22377/ajp.v7i4.338 UR - https://asiapharmaceutics.info/index.php/ajp/article/view/338 SP - AB - The present study is aimed at development and optimization of mucoadhesive nanoparticles (NPs) from natural<br />mucoadhesive polysaccharides extracted from Tamarind seeds (Tamarindus indica) for the sustained delivery of<br />anticancer drug irinotecan. The drug loaded NPs were prepared by ion gelation method with the isolated polysaccharide by<br />homogenization followed by lyophilization. The polysaccharides were cross‑linked with sodium alginate in different ratios. The<br />formulations were optimized using two level factorial design (Design Expert ‑ 8.0.7.1) using the polysaccharide to alginate<br />ratio, homogenization time and homogenization speed as independent variables and particle size (PS), drug entrapment<br />efficiency and cumulative drug release as the dependent variables. The NPs were characterized in terms of PS, entrapment efficiency, drug loading (DL), in vitro drug release and cell viability studies in mice. Stable NPs were obtained with average PS of 405 ± 25.2 nm. The preparations were homogenous showing polydispersity index of 0.497 ± 0.02. The formulation showed up to 95.36 ± 3.1% (w/w) yield showing DL of 1.0 ± 0.2% (w/w). The entrapment efficiency was found to be<br />46.56 ± 1.5% (w/w). In vitro drug release showed initial burst release followed by controlled release pattern showing up<br />to 60% release in 12 h. The average cell viability was found to be 80% in case of the control group, which was reduced to<br />36% for NPs treated groups respectively. The Fourier transform infrared studies showed no incompatibility in the formulated<br />NPs. It may be concluded from the study that tamarind seed polysaccharides may be suitable for formulation of mucoadhesive NPs for better efficacy and sustained delivery of anticancer drug irinotecan with reduced toxicity.<br />Key words: Homogenization, irinotecan, mucoadhesive, nanoparticles, tamarind ER -