TY - JOUR AU - Malakar, Jadupati AU - Nayak, Amit Kumar PY - 2014/10/01 Y2 - 2024/03/29 TI - Floating bioadhesive matrix tablets of ondansetron HCl: Optimization of hydrophilic polymer‑blends JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 7 IS - 4 SE - Articles DO - 10.22377/ajp.v7i4.341 UR - https://asiapharmaceutics.info/index.php/ajp/article/view/341 SP - AB - The work investigates the development and optimization of floating bioadhesive matrix tablets of ondansetron HCl for<br />gastroretentive delivery using 23 factorial design. The effects of xanthan gum, guar gum, carbopol 934 P as hydrophilic<br />polymer‑blends on drug release were analyzed. The optimized tablets were floated well in simulated gastric fluid (SGF)<br />(&gt;8 h) with no lag‑time and also showed a good bioadhesion time (5.23 ± 0.25 min) on goat intestinal mucosa in SGF.<br />The in vitro drug release of these tablets showed sustained ondansetron HCl release over 8 h, which correlated well with<br />controlled‑release (zero order) pattern with super case‑II transport mechanism.<br />Key words: Bioadhesion, floatation, gastroretention, matrix tablets, ondansetron HCl, polymer‑blend ER -