TY - JOUR AU - Garg, Seema AU - Chandra, Amrish AU - Mazumder, Avijit AU - Mazumder, Rupa PY - 2014/10/02 Y2 - 2024/03/28 TI - Green synthesis of silver nanoparticles using Arnebia nobilis root extract and wound healing potential of its hydrogel JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 8 IS - 2 SE - Articles DO - 10.22377/ajp.v8i2.345 UR - https://asiapharmaceutics.info/index.php/ajp/article/view/345 SP - AB - The present study reports wound healing potential of silver nanoparticles (AgNPs) hydrogel using Arnebia nobilis (A. nobilis)<br />root extract. It makes a convenient method for the green synthesis of AgNPs and evaluated for its wound healing activity.<br />Silver has been used for the treatment of medical ailments for over 100 years due to its natural antibacterial and antifungal<br />properties. The synthesized nanoparticles were characterized using UV‑visible spectrophotometer; transmission electron<br />microscopy, X‑ray diffraction (XRD), scanning electron microscopy, and Fourier transform infra‑red spectrometry. The<br />nanoparticles were found to be mostly spherical in shape. XRD study shows that the particles are crystalline in nature with<br />face centered cubic geometry. The synthesized AgNPs exhibited good antibacterial potential against both Gram‑positive and<br />Gram‑negative bacterial strain as measured using well diffusion assay. The recent emergence of nanotechnology has provided<br />a new therapeutic modality in AgNPs for use in wounds. We investigated the wound‑healing potential of AgNPs hydrogel<br />using A. nobilis root extract in an excision animal model. The study showed that hydrogel of AgNPs using A. nobilis root extract<br />exert positive effect due to their antimicrobial potential. The results provide insight into the mechanism of actions of AgNPs<br />and have provided a novel therapeutic direction for wound treatment in the clinical practice.<br />Key words: Antibacterial potential, Arnebia nobilis, Fourier transform infra‑red, silver nanoparticles, wound healing, X‑ray diffraction ER -