TY - JOUR AU - Enturi, Veeraiah AU - Chowdary, B. Yaminipurna AU - Chowdary, K. P. R. PY - 2014/10/02 Y2 - 2024/03/19 TI - Enhancement of dissolution rate and formulation development of irbesartan tablets by employing starch phosphate: A new modified starch JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 8 IS - 3 SE - Articles DO - 10.22377/ajp.v8i3.355 UR - https://asiapharmaceutics.info/index.php/ajp/article/view/355 SP - AB - The objective of the present study is to prepare, characterize, and evaluate starch phosphate as a carrier in solid dispersions<br />for enhancing the dissolution rate of irbesartan (IRB). The feasibility of formulating solid dispersions of IRB in starch<br />phosphate into compressed tablets with enhanced dissolution rate was also investigated. Starch phosphate prepared by<br />reacting starch with di‑sodium hydrogen orthophosphate anhydrous at elevated temperatures was insoluble in water and<br />has good swelling (400%) property without pasting or gelling when heated in water. Solid dispersions of IRB in starch<br />phosphate prepared by solvent evaporation method employing various weight ratios of drug: Starch phosphate gave rapid<br />and higher dissolution of IRB when compared to pure drug. The 19.92‑ and 39.98‑fold increase in the dissolution rate (K1)<br />of IRB was observed with solid dispersions ISD4 and ISD5, respectively. The dissolution efficiency up to 30 min (DE30) was<br />also increased from 10.58% in the case of IRB pure drug to 81.77% and 88.28% in the case of ISD4 and ISD5, respectively.<br />IRB tablets formulated employing its solid dispersions in starch phosphate also gave rapid and higher dissolution rate and<br />DE30 when compared to plain and commercial tablets. The 33.82‑ and 59.66‑fold increase in the dissolution rate (K1) was<br />observed with formulations IBTF2 and IBTF3 when compared to formulation IBTF1. Starch phosphate could be used as a<br />carrier to enhance the dissolution rate of IRB from its solid dispersions as well as tablet formulations.<br />Key words: Irbesartan, solid dispersions, starch phosphate, tablets and modified starches ER -