TY - JOUR AU - Swathy, Bekkeri PY - 2022/12/15 Y2 - 2024/03/28 TI - In silico Studies for Tridax procumbens Linn Phyto constituents with Anti-inflammatory Receptors JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 16 IS - 4 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v16i4.4605 UR - https://asiapharmaceutics.info/index.php/ajp/article/view/4605 SP - AB - <p>Introduction: A wound is categorized as a breakdown or opening of the skin, which could lead to<br>malfunctioning of the skin. Materials and Methods: Interleukin-1 receptor-associated kinases are key<br>components in the signal transduction pathways utilized by interleukin-1 receptor and interleukin-18 receptor.<br>Results and Discussion: The critical role of IRAK-4 in inflammatory processes, and modulation of IRAK-4<br>kinase activity presents an attractive therapeutic approach for the treatment of inflammatory diseases. To identify<br>the potent IRAK-4 inhibitors with new anti-inflammatory therapeutic agents from selected herbal plants and<br>their extract with the help of in-silico data. Conclusion: In the present study, we have investigated in silico<br>computational studies for Tridax procumbens phytoconstituents against the molecular targets involved in the<br>anti-inflammatory process. The molecular docking interactions show good binding affinity against the molecular<br>targets of the anti-inflammatory target, namely, ILAK4. Among the ligands docked against ILAK4, Nodakenin<br>(14), and Apigenin 7-O-β-D-glucoside (16) showed excellent free energy binding with dock score values of −9.4<br>and −10 kcal/mol, respectively. These results suggest that further mechanistic studies are to be done for these<br>phytoconstituents against anti-inflammation.</p> ER -